EPITHELIUM BARRIER
Epithelium barriers (gut, stomach, vagina etc.) are crucial to protect the body from pathogens, toxins, and environmental damages. When these barriers are compromised, foreign substances can trigger immune responses, leading to chronic inflammation associated with various systemic disorders including inflammatory bowel diseases, type 1 diabetes, celiac disease, multiple sclerosis, etc. .
At ACARYON we have developed a wide range of assays allowing to get insights about the epithelium protecting properties of your products.
Whether probiotics, food ingredients, plant extract or other compounds, our experts are here to help you uncover the full potential of your products.
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Let’s explore the potential of your products together.
PERMEABILITY ASSAY
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A leaking gut barrier facilitates translocation of harmful substances and the development of inflammation.
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Our permeability assay allows to test the health-promoting effect of your product on the intestinal barrier integrity.
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The effect of your product can be tested under physiological conditions, as well as in conditions simulating inflammation, bacterial infection or viral infection.
PROLIFERATION/DIFFERENTIATION ASSAY
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The intestinal epithelium is renewed every 3–5 days.
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In this assay we analyse the effect of your product on the proliferation and the differentiation of gut epithelial cells.
MUCUS PRODUCTION
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The mucus layer is the first line of defense against infiltration of components from the gut lumen. It is mainly composed of mucins produced by specific epithelial cells.
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We can analyse the effect of your products on the mucus production by gut epithelial cell lines
MICROBIOME MODULATION
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The microbiome is essential for maintaining a strong and resilient intestinal barrier-producing protective metabolites, such as short-chain fatty acids, shielding against harmful pathogens, regulating immune function for optimal gut health etc.
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With the HUMIPLATE platform, you can analyse the impact of your product on the microbiome’s protective properties.
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By testing the supernatant of microbiomes cultivated with your product, HUMIPLATE reveals its effects on epithelial integrity, permeability, and overall gut resilience.
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Discover the potential of your innovations with cutting-edge precision.
Have a non-binding consultation with one of our experts to find out the best solution for your needs.
Contact us.
