Microbial carbohydrates are:
main components of the surface of microorganisms
oriented to the environment
offer an almost unlimited diversity of structures
can be released into the environment
Consequently, microorganisms are strongly relying on carbohydrates and carbohydrate binding structures for specific regulation of their environment and of the microbiome host axis.
Microbial carbohydrates are essential for many processes including:
binding to cell receptors
binding to extracellular matrix
binding of soluble substances
binding to other microorganisms
Activation/Repression of Immune system
Cross feeding function
Signal transduction etc.
Take Advantage Of Microbial Carbohydrates For The Development Of Innovative Probiotics
What Can Help You With
You can rely on our 20 years of experience in the field of microbial carbohydrate and microbiome applications.
We analysed yet more than 10.000 strains for carbohydrate related properties.
With our MicroSIS-Platform we can screen the microbiome for microorganisms expressing specific carbohydrate structures.
Specific Anti-Infection Properties
Bacterial strains which naturally express a carbohydrate structure mimicking receptor for a pathogen, a virus or a toxin can specifically displaces the pathogen, virus or toxin and potentially avoid the related disease.
Example: Binding and neutralizing the cholera toxin. Toutounian et. al. Human Microbiome Journal, Volume 18, December 2020
Specific Immune Modulation
Bacterial strains naturally expressing or secreting specific carbohydrate structures (antigen or immune stimulatory) can stimulate the immune system.
Example: Microbial carbohydrate antigen inducing an anti-cancer immune response. Ulsemer et. al. Beneficial Microbes. 2016 Sep;7(4):485-500.
Specific Promotion Or Inhibition Of Growth
Bacterial strains naturally expressing or secreting specific carbohydrate structures can promote or inhibit the growth of other species.